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The project will be conducted in the research group of Professor Kurt Vesterager Gothelf at the Interdisciplinary Nanoscience Center and Department of Chemistry.
Research area and project description:
We overall goal of the project is to explore new methods for precise mechanical actuation of DNA nanostructures by molecules and polymers that undergo mechanochemical changes. The main objective of the project is to synthesize organic compounds that are mechanically responsive to light, such as azobenzene derivatives, organic oligomers that are mechanically switchable by electrochemistry, or by reactions induced by certain reagents. The compounds may be incorporated in oligomers or polymers and will be conjugated to DNA by automated DNA synthesis. The molecular actuators will be integrated in dynamic DNA nanostructures typically made of DNA origami, to induce actuation.
The position is for 3 years and is funded by the PhD school DNA-Robotics, a recently established Innovative Training Network (ITN) under the European Commission’s Marie Skłodowska-Curie Actions research fellowship programme. DNA-Robotics (DNABOT) will foster the development of a new generation of scientists with the skills required to meet futures challenges in bionanotechnology, from fundamental science to novel applications. The PhD study involve 3 months of secondments in total at one or more of the other partner universities in the network.
Qualifications and specific competences:
The successful candidate should have completed a masters’ degree (or equivalent) in chemistry no later than August 1, 2018. Extensive training and laboratory experience in organic synthesis is required. To qualify for funding under the rules of the Marie Skłodowska-Curie action, candidates must: i) not have lived in Denmark for more than 12 months in the last 3 years ii) not already possess a PhD degree and iii) be in the first four years of their research career, since, for example, completion of a masters’ degree.