AU: Signal transfer in DNA nanostructures

The purpose of the project is to design and explore methods for signal-transfer in and between DNA nanostructures. The candidate will use computer aided design programs to design DNA origami structures and invent DNA-based signal transfer reactions such as e.g. the hybridization chain reaction to transfer signals across the structure. Furthermore, the candidate will design interface mechanisms between the signalling system and sensor and/or actuator modules. The structures will be made by self-assembly of DNA structures and their structure and dynamics will be analysed by the candidate by atomic force microscopy, transmission electron microscopy, optical methods and other biophysical techniques.

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