The overall aim of the DNA-Robotics project is to investigate and develop artificial machinery made from DNA. DNA molecules can be programmed through design of their base sequences to form well-defined molecular architectures, which can be combined and integrated into more complex systems. At ATDBio, the appointed researcher will design and synthesise DNA origami and other DNA/RNA secondary structures that can change conformation in a controlled manner on target binding or change in environment such as pH. Changes in conformation will be measured by a number of techniques including FRET and imaging with TEM.