In this article published in ACS NANO, a DNA origami structure is shown capable of clustering DR5. When this cluster inducing origami is added to cancer cells, it is shown to cause apoptosis and cell death. As much as 80% of some cell types went into apoptosis with one version of this DNA origami structure.
This articles aims to explain the basic concepts, perspectives and the main ethical considerations regarding the concept of DNA nano-robots. This outreach paper has been written with equal contributions from all the DNA-Robotics Early stage researches. Authors are listed in random order:
Quentin Vincentini, Lorena Baranda Pellejero, Aitor Patiño Díaz, Alba Monferrer i Sureda, Michael Pinner, Yash Bogawat, Minke Nijenhuis, Angel Santorelli, Nestor Sampedro, Marco Llocaico, Igor Baars, Mihir Dass, Karol Kolataj, Joakim Bohlin, Rafael Carrascosa Marzo.
In this article we show two different approaches to produce linear actuators made from DNA
In all levels of engineering, complex machinery is based on the concerted activity of many different subunits of heterogeneous nature. One of such subunits are the linear actuators we refer to in the title. Basically, a linear actuator is a device or construct capable of producing a motion confined in one axis; this type of devices, as they are currently found in mechanisms and machines, can be as large as the ones found in the hydraulic arm of an excavator or as precise as the piezoelectric actuators capable of movements in the nanometer range.
In this work we demonstrated how to repurpose IgG antibodies to boost different chemical reactions and synthesize functional molecules.
The work has recently been published in Nature Communications. Follow this link to read the full article or read Lorena’s post below for a summary.
Analysing coarse-grained simulations of DNA and RNA nanostructures is now much easier. With the new oxView tool published by the Šulc lab, oxDNA simulations are now more accessible to experimental groups, allowing for iterative design and evaluation of structures.
The article has been published in the journal Nucleic Acid Research. Follow this link to read the full article or read Joakim’s post below for a shorter version.