Designing Nanostructures with RNA

Hello there! It’s Néstor Sampedro writing again from Aarhus, Denmark. I am part of the Andersen lab in which we are designing novel RNA molecules for biotechnological applications. Nanostructures made out of this molecule have the advantage of being produced inside cells by standard biological means. Designing RNAs is challenging but fun, on a previous blog post a cool RNA structure was shown, but how does the design of such structures work, what are the principles behind it? Keep on reading to get a sneak peek into how we use our laptops and pipettes to design RNA origami nanostructures!

Simulating DNA

Things on the nanoscale are, by definition, quite small. This poses a problem in the sense that it can be tricky to get a good look at them. Microscopes can only get you so far; although microscopy techniques are constantly improving it is still much easier (and significantly cheaper) to simulate your design at whatever level of detail you require, especially if you want to see things moving around.

How About a Sneak Peak? Into the Realm of DNA Nanotechnology!

Namaste everyone! Remember me from the last post? The guy who got interviewed by Ellen, on The Ellen Show? In his dreams? Yeah, that was me (if not check it out here). So today I will be talking about some sciency stuff because our DNA Robotics consortium is themed on DNA Nanotechnology. So, let’s slide along the strands of Functional DNA Nanotechnology (awkward attempt at generating humour):