Artificial protein-DNA conjugates: Increasing the versatility of proteins with the help of DNA

Hey there! This is Lorena, and in this post I will talk about protein-DNA conjugates, as part of the lecture course 🙂 I have recently been working quite a lot with them, so I am very excited to cover some of their aspects

Proteins have incredible properties nobody else in the bio-world has. Their highly complex tertiary structure and the richness of their chemical groups allows them to bind molecules with high affinity and in a very selective way. They are also able to act as very efficient catalysts, showing high substrate turnover ratios. Thus, it is no surprise that proteins attract a great deal of attention and are in high demand for a lot of applications.

Using antibodies to control chemical reactivity

In this work we demonstrated how to repurpose IgG antibodies to boost different chemical reactions and synthesize functional molecules.

The work has recently been published in Nature Communications. Follow this link to read the full article or read Lorena’s post below for a summary.

NOMADIC SCIENTISTS: What do you mean by home?

Something all of us the ESRs have in common, mainly because it was a requirement to take part in this network, is that we all left our home countries to start a new and rather long 3-year period abroad, either in a similar or completely different country. That is indeed a challenge we must take, especially at the beginning, and that sometimes it can even go unnoticed. We as humans need this feeling of home; a safe place where to find comfort and feel that we belong.

DNA systems powered by antibodies

Hey again!

Still following us? Then you should be about to become an expert in DNA nanotechnology! Well, maybe that was a bit too optimistic, but still, you can’t deny you already have an insight on the field thanks to Yash; you’re able to see in your laptop screen DNA structures whose sizes are 10,000 times smaller than the diameter of a human hair thanks to Joakim; and also, you witnessed the controlled movement of these little things thanks to Rafa.