DNA-based Modular Nanorobotics
This is the pre-peer reviewed version of the following article: Protein-Templated Reactions Using DNA-Antibody Conjugates, which has been published in final form at https://doi.org/10.1002/smll.202200971. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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This articles aims to explain the basic concepts, perspectives and the main ethical considerations regarding the concept of DNA nano-robots. This outreach paper has been written with equal contributions from all the DNA-Robotics Early stage researches. Authors are listed in random order:
Quentin Vincentini, Lorena Baranda Pellejero, Aitor Patiño Díaz, Alba Monferrer i Sureda, Michael Pinner, Yash Bogawat, Minke Nijenhuis, Angel Santorelli, Nestor Sampedro, Marco Llocaico, Igor Baars, Mihir Dass, Karol Kolataj, Joakim Bohlin, Rafael Carrascosa Marzo.
Hey there! This is Lorena, and in this post I will talk about protein-DNA conjugates, as part of the lecture course 🙂 I have recently been working quite a lot with them, so I am very excited to cover some of their aspects
Proteins have incredible properties nobody else in the bio-world has. Their highly complex tertiary structure and the richness of their chemical groups allows them to bind molecules with high affinity and in a very selective way. They are also able to act as very efficient catalysts, showing high substrate turnover ratios. Thus, it is no surprise that proteins attract a great deal of attention and are in high demand for a lot of applications.
In this work we demonstrated how to repurpose IgG antibodies to boost different chemical reactions and synthesize functional molecules.
The work has recently been published in Nature Communications. Follow this link to read the full article or read Lorena’s post below for a summary.
Something all of us the ESRs have in common, mainly because it was a requirement to take part in this network, is that we all left our home countries to start a new and rather long 3-year period abroad, either in a similar or completely different country. That is indeed a challenge we must take, especially at the beginning, and that sometimes it can even go unnoticed. We as humans need this feeling of home; a safe place where to find comfort and feel that we belong.
DNA-Robotics 