In thispost for online science exhibition, we will learn about examples of DNA systems powered by antibodies presented by Lorena Baranda Pellejero from Ricci’s lab at University of Rome Tor Vergata. To get some more information about each of them, Lorena goes more into detail in this explanatory post.
This figure is from the article Antibody-powered nucleic acid release using a DNA-based nanomachine (Ranallo S, Prévost-Tremblay C, Idili A, Vallée-Bélisle A, Ricci F. in Nature Commun 2017, 8, 15150).
This figure is from the article Programmable Nucleic Acid Nanoswitches for the Rapid, Single-Step Detection of Antibodies in Bodily Fluids (Porchetta A, Ippodrino R, Marini B, Caruso A, Caccuri F, Ricci F. J Am Chem Soc 2018, 140, 947-953.)
This figure is from the article Orthogonal regulation of DNA nanostructure self-assembly and disassembly using antibodies (Ranallo S, Sorrentino D, Ricci, R. Nature Commun 2019, 10, 5509)