Online Science Exhibition no. 3

In thispost for online science exhibition, we will learn about examples of DNA systems powered by antibodies presented by Lorena Baranda Pellejero from Ricci’s lab at University of Rome Tor Vergata. To get some more information about each of them, Lorena goes more into detail in this explanatory post.

200125_Lorena_ramme_1
A molecular slingshot made from DNA able to “shoot” its cargo in specific locations, i.e., where the antibody is present.

This figure is from the article Antibody-powered nucleic acid release using a DNA-based nanomachine (Ranallo S, Prévost-Tremblay C, Idili A, Vallée-Bélisle A, Ricci F.  in Nature Commun 20178, 15150).

 

200125_Lorena_ramme_2
DNA-based sensor that exhibits fluorescence when the single strands are brought into close proximity by a specific antibody.

This figure is from the article Programmable Nucleic Acid Nanoswitches for the Rapid, Single-Step Detection of Antibodies in Bodily Fluids (Porchetta A, Ippodrino R, Marini B, Caruso A, Caccuri F, Ricci F.  J Am Chem Soc 2018140, 947-953.)

 

200125_Lorena_ramme_3
Antibodies trigger the activation of DNA tiles that self-assemble to build a DNA-based nanostructure.

This figure is from the article Orthogonal regulation of DNA nanostructure self-assembly and disassembly using antibodies (Ranallo S, Sorrentino D, Ricci, R. Nature Commun 2019, 10, 5509)

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: